Martemyanov Publications

Selected Publications:

	Anderson , G.R., Posokhova E., Martemyanov K.A. (2009) The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell Biochem. Biophys. 54 , 33-46 [pdf-398kb]
	Cao Y., Masuho I., Okawa H., Xie K, Asami J., Kammermeier P., Furukawa T., Inoue Y., Sampath A.P., Martemyanov K.A. (2009) Retina specific GTPase accelerator RGS11/Gbeta5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. J. Neurosci . 29, 9301-9313. [pdf-3390kb]
	Anderson G.R., Lujan R., and Martemyanov K.A. (2009) Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits. Mol. Cell Biol . 11 , 3033-3044 . [pdf-1880kb]
	Martemyanov K.A., Krispel C.M., Lishko P.V., Burns M.E., Arshavsky V.Y. (2008) Functional comparison of RGS9 splice isoforms in a living cell. Proc. Natl. Acad. Sci. USA 105: 20988 - 20993. [pdf-779kb]
	Hooks S., Martemyanov K., and Zachariou V. (2008) A role of RGS proteins in drug addiction. Biochem. Pharmacol . 75: 76-84. [pdf-331kb]
	Kim H.J., Martemyanov K.A., Thayer S.A. (2008) Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. J. Neurosci. 28: 12604 - 12613. [pdf-552kb]
	Cao Y., Song H., Okawa H., Sampath A.P., Sokolov M., Martemyanov K.A. (2008) Targeting of RGS7/G b 5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP. J. Neurosci. 28: 10443 – 10449. [pdf-388kb]
	Anderson G.R., Lujan R., Semenov A., Pravetoni M., Posokhova E.N., Song, J.H., Uversky V., Chen C-K., Wickman K.and Martemyanov K.A. (2007) Expression and Localization of RGS9-2/Gbeta5/R7BP Complex In Vivo Is Set by Dynamic Control of Its Constitutive Degradation by Cellular Cysteine Proteases. J. Neurosci. 27: 14117-14127. [pdf-809kb]
	Song J.H., Song H., Wensel T.G., Sokolov M. and Martemyanov K.A. (2007) Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol Cell Neurosci. 35: 311-319. [pdf-405kb]
	Anderson G.R., Semenov A., Song J.H. and Martemyanov K.A. (2007) The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2. J. Biol. Chem. 282(7): 4772-4781. [pdf-547KB]
	Song J.H., Waataja J.J. and Martemyanov K.A. (2006) Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. J. Biol. Chem. 281(22): 15361-15369. [pdf-465KB]
	Baker S.A., Martemyanov K.A., Shavkunov A.S. and Arshavsky V.Y. (2006) Kinetic mechanism of RGS9-1 potentiation by R9AP. Biochemistry 45 , 10690-10697. [pdf-210KB]
	Krispel C.M., Chen D., Melling N., Chen Y.J., Martemyanov K.A., Quillinan N., Arshavsky V.Y., Wensel T.G., Chen C.K. and Burns M.E. (2006) RGS expression rate-limits recovery of rod photoresponses. Neuron. 51(4):409-16.[pdf-207KB]
	Grant J.E., Guo L.W., Vestling M.M., Martemyanov K.A ., Arshavsky V.Y. and Ruoho A.E. (2006) The N-terminus of GTPgammaS-activated transducin alpha subunit interacts with the C-terminus of the cGMP phosphodiesterase? gamma subunit. J. Biol. Chem. 281, 6194-6202. [pdf-452KB]
	Martemyanov K.A., Yoo P.J., Skiba N.P. and Arshavsky, V.Y. (2005) R7BP, a novel neuronal protein interacting with RGS Proteins of the R7 family. J. Biol. Chem. 280: 5133-5136. [pdf-198KB]
	Guo L.W., Hajipour A.R., Gavala M.L., Arbabian M., Martemyanov K.A., Arshavsky V.Y. and Ruoho A.E. (2005) Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction. Bioconjug. Chem. 16, 685-693. [pdf-513KB]
	Martemyanov K.A. and Arshavsky V.Y. (2004) Kinetic approaches to study the function of RGS9 isoforms. Methods in Enzymology. 390: 196-209. [pdf-202KB]
	Keresztes G., Martemyanov K.A., Krispel C.M., Mutai H., Yoo P.J., Maison S.F., Burns M.E., Arshavsky, V.Y. and Heller S. (2004) Absence of the RGS9/Gbeta5 GTPase activating complex in photoreceptors of the R9AP knockout mouse. J. Biol. Chem. 279: 1581-1584. [pdf-162KB]
	Nishiguchi K.M., Sandberg M.A., Kooijman A.C., Martemyanov K.A., Pott J.W., Hagstrom S.A., Arshavsky V.Y., Berson E.L. and Dryja T.P. (2004) Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. Nature. 427: 75-78. [pdf-278KB]
	Martemyanov K.A., Lishko P.V., Calero N., Keresztes G., Sokolov M., Strissel K.J., Leskov I.B., Hopp J.A., Kolesnikov A.V., Chen C.K., Lem J., Heller S., Burns M.E. and Arshavsky, V.Y. (2003) The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. J. Neurosci. 23: 10175-10181. [pdf-268KB]
	Martemyanov K.A., Hopp J.A. and Arshavsky, V.Y. (2003) Specificity of G protein-RGS protein recognition is regulated by affinity adapters. Neuron. 38: 857-862. [pdf-202KB]
	Lishko P.V., Martemyanov K.A., Hopp J.A. and Arshavsky V.Y. (2002) Specific Binding of RGS9-Gbeta5L to Protein Anchor in Photoreceptor Membranes Greatly Enhances Its Catalytic Activity. J. Biol. Chem. 277: 24376-24381. [pdf-179KB]
	Martemyanov K.A. and Arshavsky V.Y. (2002) Noncatalytic domains of RGS9-1/Gbeta5L play a decisive role in establishing its substrate specificity. J. Biol. Chem. 277: 32843-32848. [pdf-143KB]
	Skiba N.P., Martemyanov K.A., Elfenbein A., Hopp J.A., Bohm A., Simonds W.F. and Arshavsky V.Y. (2001) RGS9/Gbeta5 substrate selectivity in photoreceptors: opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. J. Biol. Chem. 276, 37365-37372. [pdf-198KB]