Juan Francisco Giménez Abián

Guest Scientist 2004

Education
• B.Sc., Biological Sciences, Sobresaliente (max. qualification). Universidad Complutense, Madrid, Spain. 1982-1987
• Ph. D., Meiotic chromosome structure and behaviour. Cum laude (max. quaification), Universidad Autónoma, Madrid, Spain. 1987-1992.

2. J. Gosálvez, López Fernández, J.L. Bella, J. de la Torre, J.M. Rubio, J.F., Giménez-Abián and M. Westermann. Divergence of sex chromosomes and autosomes in Podisma (Orthoptera). An overview. Life Sciences: Advances-Genetics (Council of Scientific Research Integration), 7: 225-229, 1988

3. J.S. Rufas, J.F. Giménez-Abián, C. García de la Vega and J. Gosálvez. Recombination within extra segments: evidence from the grasshopper Chortippus jucundus. Chromosoma, 96: 95-101, 1988

4. M.I. Giménez-Abián, G. Giménez Martín, J.F. Giménez-Abián. Relaciones núcleo-citoplásmicas en el ciclo proliferativo. In GENETICA. CEURA eds. Pgs. 41-63, 1989

5. J.F. Giménez-Abián, G. Giménez Martín, J.A. Suja and J.S. Rufas. Nucleolar organizer regions are associated with silver-stained chromatid cores in meiotic chromosomes of grasshoppers. Genome, 32: 829-833, 1989.

6. J.A. Suja, J. De la Torre, J.F. Giménez-Abián, C. García de la Vega and J.S. Rufas. Meiotic chromosome structure. kinetochores and chromatid cores in standard and B-chromosomes of Arcyptera fusca (Orthoptera) revealed by silver staining. Genome, 34: 19-27, 1991.

7. C. De la Torre, J.F. Giménez-Abián and A. González Fernández. Dominance of a NOR (nucleolar organizer region) over its allele and over its sister NOR after asymmetric 5-azacytidine substitution in plant chromosomes. Journal of Cell Science, 100: 667-674, 1991

8. D.J. Clarke, J.F. Giménez-Abián, A.M. Mullinger, R.T. Johnson and C.S. Downes. DNA topoisomerase II and the 'decatenation adequate?' cell cycle checkpoint. Molecular Biology of the Cell, 5: 82, 1994.

9. C.S. Downes, D.J. Clarke, A.M. Mullinger, J.F. Giménez-Abián, A.M. Creighton and R.T. Johnson. A topoisomerase -II- dependent G2 cycle checkpoint in mammalian cells. Nature, 372: 467-470, 1994

10. J.F. Giménez-Abián, D.J. Clarke. Cell Cycle. Checkpoints. Scientific American, 226: 40-41, 1995.

11. J.F. Giménez-Abián, D.J. Clarke, A.M. Mullinger, C.S. Downes and R.T. Johnson. A post-prophase topoisomerase-II dependent chromatid core separation step in the formation of metaphase chromosomes. Journal of Cell Biology, 131: 7-17, 1995.

12. C.S. Downes, D.J. Clarke, H. Tönnies, J.F. Giménez-Abián, A.M. Mullinger, K. Sperling and R.T. Johnson. Generation of partial monosomies in human somatic cells by inhibition of mitotic DNA topoisomerase II. Chromosome segregation and aneuploidy . A. Abbondandolo; V.K. Vig and R. Roi, eds., IST., 133-137, 1996.

13. M.I. Giménez-Abián, J.F. Giménez-Abián, A. Cuadrado, H.R. Pelayo, G. Giménez-Martín and C. de la Torre. The development of intraspecific dominance in some nucleolar organizer regions of plants. Plant Cell Proliferation and its Regulation in Growth and Development. J. Bryant eds. Chapter 12, pg. 167-183, 1997

14. J. Sans, C. Leyton, M.I. Giménez-Abián, J.F. Giménez-Abián, P. Aller and C. de la Torre. Default cycle phases determined by the inactivation of specific DNA sequences in meristematic cells. Cell Proliferation, 30: 61-69, 1997.

15. C. de la Torre, M.I. Giménez-Abián, J.F. Giménez-Abián, M. Hernández-Navarrete, F. Panzera, J. F. López-Sáez, L. Bögre and E. Heberle-Bors. The induction of polyploids and aneuploids in plant cells. Cell Biology International, 21: 859-860, 1997.

16. J.F. Giménez-Abián, D.J. Clarke, C. García de la Vega and G. Giménez-Martín. The role of sister chromatid cohesiveness and structure in meiotic behaviour. Chromosoma, 106: 422-434, 1997.

17. D.J. Clarke, J.F. Giménez-Abián, H. Tönnies, H. Neitzel, K. Sperling, C.S. Downes and R.T. Johnson. Creation of monosomic derivatives of human cultured cell lines. Proc. Natl. Acad. Sci., 95: 167-171, 1998.

18. M.I. Giménez-Abián, F. Panzera, J. F. López-Sáez, J.F. Giménez-Abián, C. De la Torre and G. Giménez-Martín. Immediate disruption of spindle poles and induction of additional microtubule-organizing centers by a phenylcarbamate, during plant mitosis. Protoplasma, 204: 119-127, 1998.

19. J.F. Giménez-Abián, D.J. Clarke, C. De la Torre, G. Giménez-Martín, A.M. Mullinger, C.S. Downes and R.T. Johnson. Competence for assembly of sister chromatid cores is progressively acquired during S phase in mammalian cells. European Journal of Cell Biology, 78: 601-603, 1999.

20. D.J. Clarke and J.F. Giménez-Abián. Checkpoints controlling entry into mitosis. Bioessays, 22: 351-363, 2000

21. J.F. Giménez-Abián, D.J. Clarke, J. Devlin, M.I. Giménez-Abián, C. De la Torre, R.T. Johnson, A.M. Mullinger and C.S. Downes. Premitotic chromosome individualization in mammalian cells depends on topoisomerase II activity. Chromosoma, 109: 235-244, 2000.

22. D.J. Clarke, A.P.L. Smith and J.F. Giménez-Abián. DNA-damaging-independent checkpoints from yeast to man. Cell cycle checkpoints and cancer. Mikhail Blagosklonny, Ed. Landes Bioscience. p78-105.

23. J.F. Giménez-Abián, D.J. Clarke, M.I. Giménez-Abián, C. De la Torre and G. Giménez-Martín. Synchronous onset of anaphase and nuclear envelope breakdown in plant multinucleate cells. Protoplasma, 218:192-202, 2001.

24. J.F. Giménez-Abián, D.J. Clarke, G. Giménez-Martín, M. Weingarttner, M.I. Giménez-Abián, J.A. Carballo, L. Bögre, S. Moreno Díaz de la Espina and C. De la Torre. DNA catenations that link sister chromatids until the onset of anaphase are maintained by a checkpoint mechanism. European Journal of Cell Biology, 81: 9-16, 2002.

25. A.P.L. Smith, J.F. Giménez-Abián and D.J. Clarke. DNA-damage-independent checkpoints: Yeast and higher eukaryotes. Cell Cycle, 1(1): 16-33, 2002.

26. J.F. Giménez-Abián, M. Weingartner, P. Binarova, D.J. Clarke, R.G. Anthony, O. Calderini, E. Heberle-Bors, S. Moreno Díaz de la Espina, L. Bögre and C. de la Torre. A topoisomerase II-dependent checkpoint in G2-phase plant cells can be bypassed by ectopic expression of the mitotic cyclin B2. Cell Cycle, 1(3): 187-192, 2002.

27. I.C. Waizenegger, J.F. Giménez-Abián, D. Wernic and J.-M. Peters. Regulation of human separase by securin binding and autocleavage. Current Biology, 12: 1368-1378, 2002.

28. J.F. Giménez-Abián and D.J. Clarke. Replication-Coupled Topoisomerase II Templates the Mitotic Chromosome Scaffold? Cell Cycle, 2(3): 230-232, 2003.

29. G. Giménez-Martín, J.F. Giménez-Abián and M.I. Giménez-Abián. Bases celulares del ciclo proliferativo. Cancer. pg.: 23-69. Instituto de España. Editores: García Barreno, Espinós Pérez y Cascales Angosto. Madrid. 2003.

30. A. Del Campo, R. Samaniego, J.F. Giménez-Abián, G. Giménez-Martín, J.F. López-Sáez, S. Moreno Díaz de la Espina and C. De la Torre. G2 checkpoint targets late replicating DNA. Biology of the Cell, 95 (8): 521-526, 2003.

31. H.R. Pelayo, J. Pincheira, J.F. Giménez-Abián, D.J. Clarke and C. De la Torre. P53-independent checkpoint controls in a plant cell model. Biological Research, 36: 381-388, 2003.

32. Wirth KG, Ricci R, Giménez-Abián JF, Taghybeeglu S, Kudo NR, Jochum W, Vasseur-Cognet M and Nasmyth K. Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes & Dev. 18(1):88-98, 2004.

33. Giménez-Abián JF, Sumara I, Hirota T, Hauf S, Gerlich D, De La Torre C, Ellenberg J, Peters JM. Regulation of Sister Chromatid Cohesion between Chromosome Arms. Curr Biol. 14(13):1187-93, 2004.

34. Sumara I, Giménez-Abián JF, Gerlich D, Hirota T, Kraft C, De La Torre C, Ellenberg J, Peters JM. Roles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles. Curr Biol. 14(19):1712-22, 2004.

35. Giménez-Abián JF, Díaz-Martínez LA, Wirth K, Andrews CA, Giménez-Martín G and Clarke DJ (2005). Regulated Separation of Sister Centromeres depends on the Spindle Assembly Checkpoint but not on the Anaphase Promoting Complex/Cyclosome. Cell Cycle, 4(11): 1559-1573.

36. Giménez-Abián JF, Díaz-Martínez LA, Waizenegger IC, Giménez-Martín G and Clarke DJ (2005). Separase is required at multiple pre-anaphase cell cycle stages in human cells. Cell Cycle, 4(11): 1574-1582.

37. Giménez-Abián JF, Díaz-Martínez LA, Wirth K, De la Torre C and Clarke DJ (2005). Proteasome activity is required for centromere separation independently of securin degradation in human cells. Cell Cycle, 4(11): 1556-1558.

38. Andrews CA, Giménez-Abián JF, Díaz-Martínez LA, Guacci V, Vas AV and Clarke DJ (2005). Evidence that the yeast spindle assembly checkpoint has a target other than the anaphase promoting complex. Cell Cycle, 4(11): 1553-1555.

39. Clarke DJ, Díaz-Martínez LA and Giménez-Abián JF (2005). Anaphase Promoting Complex or Cyclosome? Cell Cycle, 4(11): 1583-1590.