University of Minnesota, Twin Cities 2000-presentAssistant Professor of Biomedical Engineering
Member, Graduate Faculty of Chemical Engineering
and Materials Science
University of Colorado, Boulder 1997-2000
Assistant Professor of Chemical Engineering
M. I. T. School of Chemical Engineering Practice
1989-1991
Assistant Director, Midland Station 1989-1991
Assistant Director, Albany Station 1989EDUCATION University of Minnesota 1991-1996Postdoctoral Associate 1996Advisors: Professor Linda R. Petzold (Computer
Science)
Professor Robert T. Tranquillo (Chemical
Engineering)Research Topics: Optimized design of bioartificial
tissue; mechanical modeling of viscoelastic fluid behavior in biological
and nonbiological systemsPh. D., Chemical Engineering 1996Thesis Advisor: Professor Robert T. Tranquillo
Thesis Title: Anisotropic Biphasic Modeling
of Cell-Collagen Mechanical Interactions in Tissue EquivalentsM. I. T. 1984-1989M. S., Chemical Engineering Practice 1989
B. S., Chemical Engineering 1988
AWARDS University of Colorado Junior Faculty Development
Award 1997
Outstanding Undergraduate Teaching Award, U. of
Colorado Chemical Engineering Dept. 2000
Digital Media Center Technology-Enhanced Learning
Faculty Fellowship 2000
REFEREED PUBLICATIONS
Agoram, B. and V. H. Barocas (2000). "Coupled macroscopic
and microscopic scale modeling of fibrillar tissues and tissue equivalents"
J.
Biomech. E., submitted.
Heys, J. J. V. H. Barocas, and M. J. Taravella (2000).
"Modeling Passive Mechanical Interaction between the Aqueous Humor and
Iris." J. Biomech. E., submitted.
Xu, J., J. J. Heys, V. H. Barocas, and T. W. Randolph,
"Permeability and Diffusion in Vitreous Humor: Implications for Drug Delivery."
Pharm.
Res., 17 (6) : 664-669.
Ohsumi, T. K., V.H. Barocas, J.E. Flaherty, S. Adjerid,
and M. Aiffa (2000). "Adaptive Finite Element Analysis of Biphasic Equations."
Comp.
Meth. Biomech. Biomed. Eng., 3 : 215-229.
Lengsfeld, C. S., J. P. Delplanque, V. H. Barocas, and
T. W. Randolph (2000). "Mechanism governing microparticle morphology during
precipitation by a compressed antisolvent: atomization vs. nucleation and
growth." J. Phys. Chem. B, 2000 (104) : 2725-2735.
Knapp, D. M., V. H. Barocas, T. T. Tower and R. T. Tranquillo
(1999). "Estimation of cell traction and migration in an isometric cell
traction assay." AIChE Journal , 45 (12) : 2628-2640.
Heys, J. J. and V. H. Barocas (1998). "Mechanical Characterization
of the Bovine Iris." J Biomechanics, 32 : 999-1003.
Barocas, V. H., T. S. Girton, and R. T. Tranquillo (1998).
"Engineered Alignment in Media-Equivalents: Consequences of Cell Induced
Compaction on Magnetic Prealignment." J Biomech E., 120 (5)
: 660-666.
Zhang, X. D., D. W. Giles, V. H. Barocas, K. Yasunaga,
and C. W. Macosko (1998). "Measurement of foam modulus via a vane rheometer."
J
Rheol, 42(4) : 871-889.
Barocas, V. H. and R. T. Tranquillo (1997). "An anisotropic
biphasic theory of tissue-equivalent mechanics: the interplay among cell
traction, fibril network deformation, and contact guidance." J Biomech
Eng, 119 (2) : 135-147.
Barocas, V. H. and R. T. Tranquillo (1997). "A finite
element solution for the anisotropic biphasic theory of tissue-equivalent
mechanics: the effect of contact guidance on isometric cell traction measurement."
J Biomech Eng, 119 (3) : 261-269.
Knapp, D. M., V. H. Barocas, K. Yoo, L. R. Petzold,
and R. T. Tranquillo (1997). "Rheology of reconstituted type I collagen
gel in confined compression." J Rheol., 41 (5) : 971-993.
Barocas, V. H., A. G. Moon and R. T. Tranquillo (1995).
"The fibroblast-populated collagen microsphere assay of cell traction force
- Part 2. Measurement of the cell traction parameter." J Biomech Eng.
117
(2)
: 161-170.
NON-REFEREED PUBLICATIONS
Tranquillo, R. T. and V. H. Barocas (1997). "A continuum
model for the role of fibroblast contact guidance in wound contraction."
in Dynamics of Cell and Tissue Motion. Alt, W., Deutsch, A., Dunn,
G., eds.
Barocas, V. H. and R. T. Tranquillo (1994). Biphasic
theory and in vitro assays of cell-fibril mechanical interactions
in tissue-equivalent collagen gels. in Cell Mechanics and Cellular Engineering.
Mow, V. C., Guilak, F., Tran-Son-Tay, R., Hochmuth, R. M. 185-209.
SEMINARS
Lawrence Livermore National Laboratories, Center for
Applied Scientific Computing, Livermore, CA, 2000.
University of Minnesota, Institute for Mathematics and
Applications, Minneapolis, MN, 2000.
University of Colorado, Condensed Matter Physics Subgroup,
Boulder, CO, 1999.
University of Minnesota, Department of Biomedical Engineering,
Minneapolis, MN, 1999.
Colorado State University, Department of Chemical Engineering,
Fort Collins, CO, 1999.
UC - Santa Barbara, Department of Mechanical Engineering,
Santa Barbara, CA, 1999.
University of Florida, Department of Chemical Engineering,
Gainesville, FL, 1998.
Rensselaer Polytechnic Institute, Department of Biomedical
Engineering, Troy, NY, 1998.
Schneider (USA) Inc., Plymouth, MN, 1997.
University of Colorado, Department of Applied Mathematics,
Boulder, CO, 1997.
University of Colorado, Department of Chemical Engineering,
Boulder, CO, 1996.
University of Wisconsin, Rheology Research Center, Madison,
WI, 1996.
University of Wisconsin, Department of Chemical Engineering,
Madison, WI, 1996.
University of Massachusetts, Department of Chemical
Engineering, Amherst, MA, 1996.
UCLA, Department of Chemical Engineering, Los Angeles,
CA, 1996.
Rensselaer Polytechnic Institute, Scientific Computing
Research Center, Troy, NY, 1996.
University of Pennsylvania, Department of Chemical Engineering,
Philadelphia, PA, 1995.
Johns Hopkins University, Department of Chemical Engineering,
Baltimore, MD, 1995.
University of Delaware, Department of Chemical Engineering,
Newark, DE, 1995.
UC - Santa Barbara, Department of Chemical and Nuclear
Engineering, Santa Barbara, CA, 1995.
ORAL PRESENTATIONS
(Speaker in BOLD)
J. J. Heys, V. H. Barocas, M. J. May, and M.
Taravella, "Modeling Passive Iris Deformation with Application to Pigmentary
Glaucoma." BMES Annual Meeting, Seattle, WA. October, 2000.
V. H. Barocas, "Discrete vs. Continuum Models
of Tissue-Equivalents." BMES Annual Meeting, Seattle, WA. October, 2000.
V. H. Barocas, J. E. Flaherty, and T. K. Ohsumi,
"Adaptive Computational Techniques for Designing Bioartificial Arteries."
First SIAM Conference on Computational Science and Engineering, Washington,
DC. September, 2000.
M. L. Lipscomb, V. H. Barocas, L. A. Leinwand,
and K. W. Haubold, "Development of a Three-Dimensional In Vitro
Myocardial Equivalent." Southern Bioengineering Conference, Blacksburg,
VA. April, 2000.
J. J. Heys and V. H. Barocas, "Role of Blinking
in Pigmentary Glaucoma." AIChE National Meeting, Dallas, TX. November,
1999.
B. Agoram, T. L. Yoder, P. W. Todd, and V. H. Barocas,
"Modeling intracellular mechanics in gravitropism." AIChE National Meeting,
Dallas, TX. November, 1999.
P. J. Enever, B. A. Bromberek, M. D. Caldwell,
V. H. Barocas, and R. T. Tranquillo, "Characterizing the Effect of Platelet-Derived
Growth Factor (PDGF) BB on Fibroblast Random Migration, Chemotaxis, and
Traction in a Series of In Vitro Fibrin Gel Assays." AIChE National Meeting,
Dallas, TX. November, 1999.
B. Agoram and V. H. Barocas, "Coupled Macroscopic-Microscopic
Modeling of Collagenous Materials." AIChE National Meeting, Dallas, TX.
November, 1999.
Heys, J. J. and V. H. Barocas, "Mathematical
Modeling of Fluid Mechanics in the Eye." Colorado Biotechnology Symposium,
Boulder, CO, September 1999.
Perry, W., V. H. Barocas and D. E. Clough, "Implementing
Computational Methods into Classes Throughout the Undergraduate Curriculum."
American Society for Engineering Education Annual Conference, Charlotte,
NC, June 1999.
L. R. Petzold, V. H. Barocas, J. E. Flaherty,
P. E. Gill, E. Glinert, J. B. Rosen, B. Sczymanski, and R. T. Tranquillo,
"A High-Performance Problem-Solving Environment for Optimization and Control
of Chemical and Biological Processes." SIAM National Meeting, Atlanta,
GA, May 1999.
D. M. Knapp, T. T. Tower, V. H. Barocas, and R. T.
Tranquillo, "Mechanical Stress In Tissue-Equivalents Modulates Cell
Traction." ASME/AIChE Summer Bioengineering Conference, Big Sky, MT. June
1999.
J. J. Heys, V. H. Barocas, and M. J. Taravella,
"Mathematical Modeling of Eye Dynamics." AIChE National Meeting, Miami,
FL. November, 1998.
V. H. Barocas, T. W. Randolph, and J. Xu, "Ocular
Delivery of Hydrophobic Ion-Paired Drugs Using Biodegradable Microspheres
Produced by Gas Antisolvent Precipitation." AIChE National Meeting, Miami,
FL. November, 1998.
B. Agoram and V. H. Barocas, "Prediction of Macroscopic
Behavior of Collagen Networks Based on Microscopic Properties." AIChE National
Meeting, Miami, FL. November, 1998.
Connon, C. S., Barocas, V. H., and T. W. Randolph,
"Application of jet breakup models to systems with low liquid-gas density
ratios and high miscibilities." Los Alamos Days, Boulder CO. April, 1998.
V. H. Barocas, J. H. Heys, and M. J. Taravella,
"Contribution of Aqueous Humor Flow to Iris Displacement in Pigmentary
Dispersion Syndrome." AIChE National Meeting, Los Angeles, CA. November,
1997.
V. H. Barocas, J. H. Heys, and M. J. Taravella,
"Finite Element Simulation of Aqueous Humor Flow." US National Congress
on Computational Mechanics, San Francisco, CA. August, 1997.
V. H. Barocas and L. R. Petzold, "Finite element
simulation of transient viscoelastic flows." AIChE National Meeting, Chicago,
IL. November, 1996.
V. H. Barocas, T. S. Girton, and R. T. Tranquillo,
"Modeling and Design of Oriented Collagen-Based Tissue Analogs." AIChE
National Meeting, Miami, FL. November, 1995.
V. H. Barocas, D. M. Knapp, and R. T. Tranquillo,
"Biphasic Mechanical Theory of Fibrillar Gels." ASME/AIChE/AICE Summer
Bioengineering Conference, Beaver Creek, CO. June 1995.
V. H. Barocas and R. T. Tranquillo, "FEM Solution
of Biphasic Equations for a Cell-Populated Viscoelastic Fluid System."
ASME/AIChE/AICE Summer Bioengineering Conference, Beaver Creek, CO. June
1995.
V. H. Barocas and R. T. Tranquillo, "Biphasic
Theory of Cell-ECM Mechanical Interactions in Tissue-Equivalent Gels."
AIChE National Meeting, San Francisco, CA. November, 1994.
V. H. Barocas and R. T. Tranquillo, "Biphasic
Theory of Cell-Fibril Mechanical Interactions in Tissue-Equivalent Gels."
ASME National Meeting, Chicago, IL. November 1994.
V. H. Barocas and R. T. Tranquillo, "Biphasic
Theory and in Vitro assays of Cell-Fibril Mechanical Interactions
in Tissue-Equivalent Gels." BMES National Meeting, Memphis, TN. May 1994.
POSTER PRESENTATIONS
(speaker in bold)
M. W. Weber, A. R. Greenberg, V. H. Barocas,
and W. B. Krantz, "Development of a Nanofiltration Model for Laminar, Cross-Flow
Conditions." NAMS National Meeting, Boulder, CO, June 2000.
M. J. May, J. J. Heys, V. H. Barocas, and M.
J. Taravella, "Mathematical Modeling of Aqueous Humor Dynamics." ARVO Annual
Meeting, Ft. Lauderdale, FL, May, 2000.
K. Lankford, M. W. Weber, V. H. Barocas, A. R.
Greenberg, and W. B. Krantz, "Characterization of Nanofiltration." AIChE
National Meeting, Dallas, TX, November, 1999.
J. Xu, V. H. Barocas, and T. W. Randolph "Controlled
Release And The Concentration Distribution In The Vitreous Humor." ASME/AIChE
Summer Bioengineering Conference, Big Sky, MT. June 1999.
B. Agoram and V. H. Barocas "Prediction Of Macroscopic
Behavior Of Collagen Networks Based On Microscopic Properties." ASME/AIChE
Summer Bioengineering Conference, Big Sky, MT. June 1999.
J. J. Heys, M. J. Taravella, and V. H. Barocas
"Biomechanics Of The Aqueous Humor And Iris In Pigmentary Glaucoma." ASME/AIChE
Summer Bioengineering Conference, Big Sky, MT. June 1999.
V. H. Barocas, C. S. Connon, and T. W. Randolph,
"Liquid-Jet Break-Up in Systems with Low Liquid-Gas Density Ratios and
High Miscibilities." AIChE National Meeting, Miami, FL. November, 1998.
J. J. Heys and V. H. Barocas, "Mathematical Modeling
of Fluid Mechanics in the Eye." AAAS Regional Meeting. Mesa, CO. May 1998
B. Agoram and V. H. Barocas, "Prediction of Macroscopic
Behavior of Random Networks." AAAS Regional Meeting. Mesa, CO. May 1998
J. J. Heys and V. H. Barocas, "Mathematical Modeling
of Fluid Mechanics in the Eye." Los Alamos Days, Boulder, CO. April 1998
B. Agoram and V. H. Barocas, "Mechanical Behavior
of Random Networks." Los Alamos Days, Boulder, CO. April 1998
POST-DOCTORAL ASSOCIATES SUPERVISED
Rother, M. 8/00-present
GRADUATE STUDENTS SUPERVISED
Former Students
Agoram, B. Ph. D. 7/00. Thesis title "A Macroscopic-Microscopic
Model of Fibrillar Materials"
Lipscomb, M. M. S. 7/00. Thesis title "Development
of a Three Dimensional In Vitro Tissue Equivalent"
Weber, M. M.S. 11/00. Thesis title "Modelling
Transport and Understanding Nanofiltration"
Xu, J. (co-advised with T. Randolph), M.S 5/99.
Thesis title "Ocular Delivery of Hydrophobic Ion-Paired Drugs Using Biodegradable
Microspheres Produced by Gas Antisolvent Precipitation."
Current Students
Chandran, P. Ph. D. student, expected degree
1/04. Tentative thesis title "Intraocular Biomechanics and transport."
Heys, J. M. S. 7/98. Thesis title "Mathematical
Modeling of Fluid Mechanics in the Eye." Ph. D. student, expected
degree 6/01. Tentative thesis title "Role of Fluid Mechanics in Pigmentary
Glaucoma."
Sengupta, S. Ph. D. student, expected degree
1/04. Tentative thesis title "Measurement and Control of High-Viscosity and Particle-Laden Flows in Closed Microchannels."
Stay, M. M.S. 12/00. Thesis title "Design,
Simulation, and Performance of Peristaltic Micropumps." Ph. D. student,
expected degree 1/03. Tentative thesis title "Simulation and Optimization
of Microfluidic and Microchemical Devices."
Volovsek, R. (co-advised with J. Bischof)
M. S. student, expected degree 6/02. Tentative thesis title "In Vitro
Tissue-Equivalent Cryo-Injury Model."